Drug Metabolism and Pharmacokinetics (DMPK) play a critical role in the process of Drug Discovery and Development. Balanced properties are required to have a succesful drug candidate.
We provide integrated ADME-DMPK, metabolomics, lipidomics, and proteomics solutions to support drug discovery and development. Using advanced mass spectrometry, we deliver key insights into drug metabolism, pharmacokinetics, and molecular mechanisms to enhance efficacy, safety, and precision health research. We provide high-quality, data-driven insights tailored to your research needs.
Identifying small molecules, lipids and proteins that help predict drug metabolism, efficacy and toxicity.
Studying how drug molecules interact with their intended biological targets to optimize pharmacokinetics and pharmacodynamics.
Evaluating and selecting potential drug candidates based on ADME-DMPK properties to evaluate toxicity or uncover metabolic pathways.
At oloBion, we provide cutting-edge ADME-DMPK services designed to empower researchers and industries, including Pharmaceutical & Biotechnology, Biomedicine & Health Research, Cosmetics & Dermatology and Veterinary & Animal Science. With the support of advanced mass spectrometry platforms and the expertise of our team, we help you study Absoprtion, Distribution, Metabolism and Excretion of your analytes driving discovery, innovation, and impactful solutions. We offer both Untargeted and Targeted assays tailored to your specific needs.
In vitro metabolic stability in liver microsomes, hepatocytes, and plasma, with metabolite profiling and reaction phenotyping to support ADME evaluation and compound selection in preclinical drug discovery.
Preclinical pharmacokinetics in rodents and non-rodents, including tissue distribution, renal excretion, and PK/PD studies to characterize exposure and support candidate progression.
Plasma, tissue, and red blood cell binding studies to determine unbound fraction and support exposure assessment, species comparison, and pharmacokinetic modeling in preclinical drug development.
Caco-2 permeability studies to assess compound absorption and P-gp/BCRP transporter interactions, supporting ADME characterization and compound prioritization in preclinical drug discovery.
In vitro CYP inhibition, time-dependent inhibition, induction, and P-gp/BCRP interaction studies to assess drug–drug interaction risk and support ADME evaluation in preclinical development.
Quantitative LC–MS/MS bioanalysis of compounds and biomarkers across plasma, serum, urine, blood, and tissues to support ADME, pharmacokinetics, and preclinical development.
Pharmacoproteomics analysis to identify key proteins and determine proteomic biomarkers related to drug metabolism, transport, and resistance mechanisms, supporting mechanistic insight in preclinical research.
Pharmacolipidomics analysis to identify key lipid classes and determine lipid biomarkers related to bioavailability, metabolism, and compound response, supporting ADME and mechanistic evaluation in preclinical studies.
Pharmacometabolomics studies to identify key metabolic pathways and determine metabolomic biomarkers associated with compound exposure and metabolic response, supporting ADME and mechanistic insight in preclinical research.
More applications: Lipidomics | Metabolomics | Proteomics | Bioinformatics | Olink® | Ionomics | Caroteomics | Nutritional analysis
Transform your omics data into actionable insights with oloMAP Portal, our interactive platform for advanced statistical analysis and visualization.
Combine multiple omics datasets to uncover relationships between biological layers, gain a holistic view of underlying processes and identify potential biomarkers.
Comprehensive biological interpretation from our experts to connect omics data with biological pathways, highlighting relevant mechanisms and potential biomarkers tailored to your study.
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Standard Delivery Time:
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Partner with us to explore the power of omics in your field. Our team is ready to guide you through the process and deliver insights tailored to your research or industry needs.
Contact us today to discuss your project or schedule a consultation. Together, we’ll advance innovation through ADME-DMPK!