Is an emerging discipline that studies the interaction of drugs with the proteome, enabling a better understanding of mechanisms of action, resistance, and treatment toxicity. Its integration complements ADME-Tox and pharmacometabolomics studies, providing key information for the optimization of personalized therapies.
Selection of Proteins and Biomarkers
- Identify key proteins involved in:
- Drug metabolism and transport (cytochrome P450 enzymes, membrane transporters)
- Mechanisms of drug resistance
- Immune response and drug-induced toxicity
- Determine proteomic biomarkers to assess therapeutic efficacy and toxicity